• Users Online: 61
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2018  |  Volume : 1  |  Issue : 2  |  Page : 64-69

Characterization of a new membrane from concentrated growth factors associated with denaturized Albumin (Alb-CGF) for clinical applications: A preliminary study


1 Department of Molecular and Cell Biology, Institute of Biology, Fluminense Federal University, Brazil; Department of Surgical Sciences and Integrated Diagnostics, University of Genova, Genova, Italy; Department of Oral Surgery, Dentistry School, Federal Fluminense University, Niterói, Brazil
2 Department of Surgical Sciences and Integrated Diagnostics, University of Genova, Genova, Italy
3 Department of Molecular and Cell Biology, Institute of Biology, Fluminense Federal University, Niterói, Brazil
4 Private Clinical Practice, United States
5 Brazilian Center for Physics Research, Rio De Janeiro, Brazil
6 Department of Oral Surgery, Dentistry School, Federal Fluminense University, Niterói, Brazil

Correspondence Address:
Prof. Carlos Fernando de Almeida Barros Mourão
Rua Miguel de Frias 9, Icaraí, Niterói, Rio de Janeiro 24220-900

Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/GFSC.GFSC_21_18

Rights and Permissions

Background: One of the main issues pertaining to the use of fibrin membranes today, is their clinical efficacy for guided bone regeneration. This requires the need for membrane stability and a controlled resorption that enables the barrier to remain functionally during a relevant clinical time span. Human serum albumin is known to have an impact in the formation and stability of the fibrin networks density and permeability. Therefore, its interaction with fibrin aggregates may provide interesting features to autologous blood-derived biomaterials. Aim: In this context, the present study sought to characterize membranes produced through a modified protocol for concentrated growth factors (CGF) associated with activated plasma albumin gel (APAG). Method: Mixing denaturized albumin with CGF from the same blood samples into glass containers resulted in solid malleable membranes, with a modified denser ultrastructure as revealed by scanning electron microscopy (SEM). Results: The membranes presented a high density of nucleated cells, uniformly distributed along its length, and were able to release growth factors such as PDGF, VEGF, and FGF2 for 7 days. Conclusion: This preliminary study indicates that the protocol may provide autologous moldable and stable biomaterials for use as a soft tissue barrier, offering the basis for further research on its effectiveness for guided tissue regeneration.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1752    
    Printed112    
    Emailed0    
    PDF Downloaded237    
    Comments [Add]    

Recommend this journal