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   Table of Contents - Current issue
Coverpage
September-December 2018
Volume 1 | Issue 3
Page Nos. 79-105

Online since Thursday, November 8, 2018

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EDITORIAL  

Translational research with autologous biomaterials: A new perspective p. 79
Carlos Fernando De Almeida Barros Mourão
DOI:10.4103/GFSC.GFSC_28_18  
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ORIGINAL ARTICLES Top

Controversies related to scientific report describing g-forces from studies on platelet-rich fibrin: Necessity for standardization of relative centrifugal force values p. 80
Richard Miron, Joseph Choukroun, Shahram Ghanaati
DOI:10.4103/GFSC.GFSC_23_18  
Leukocyte and platelet-rich fibrin (PRF), a second-generation platelet concentrate has been the focus of intensive research endeavors over the last 2 decades. Over the years, numerous reports have however failed to accurately report g-force values which have caused considerable confusion in the field. These values have since been re-transcribed incorrectly in many studies moving forward, and this article aims to address this topic to avoid further confusion in the field. We address several reports in which PRF centrifugal g-forces have been calculated at the PRF clot (referred to as relative centrifugal force [RCF]-clot) as opposed to the international standard method described at the bottom of centrifugation tubes (RCF-max). We further highlight how RCF-clot is not only a deviation from the standard international method used to report g-force values, but one subject to significant error owing to centrifugation time, patient hematocrit levels, initial volume of blood collected, and other factors. For these reasons and those further reported throughout this article, we address this controversy in detail to avoid further confusion regarding the report of g-force values in future studies. Furthermore, we propose a standardization regarding the accurate report of g-force values in future studies investigating PRF at the RCF-max.
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New bovine bone graft with integrated atelocollagen Type I in artificial defects. Histologic and histomorphometric study in sheep p. 90
Paolo Trisi, Marco Berardini, Antonello Falco
DOI:10.4103/GFSC.GFSC_24_18  
Background: A new natural bovine bone grafting material with incorporated Type I atelocollagen has been recently introduced for the use in regenerative dentistry. Aims: The aim of the study was to evaluate the bone regeneration obtained using bovine bone graft with integrated atelocollagen Type I in artificial jaw bone defects, in sheep. Setting and Design: This is an in vivo study using an animal model (sheep). Materials and Methods: Four hollow titanium cylinders 4.0-mm internal diameter and 8-mm length, termed “bone growing chambers” (BGC), were inserted in two sheep mandibles. In the right side of each animal, the BGC was filled by the novel natural bovine bone graft with integrated atelocollagen Type I (test group), while the left BGC was left empty to be filled only by blood clot (control group). After 2 months of healing, the animals were sacrificed, and both histological and morphometric analysis were performed. Statistical Analysis Used: A nonparametric Mann–Whitney test was used. Results: All titanium chambers were well osseointegrated after 2 months of healing. In the test group, newly formed bone mixed with residual granules appeared incorporated in the new trabeculae. The histomorphometric analysis revealed a total bone volume percentage of 52.01 ± 8.62 for the test group and 33.72 ± 18.18 for the control group. Conclusion: The bone structure observed in the test group was more compact than the control group. This result could be attributed only partially to the presence of newly formed bone mixed to residual granules of grafting material. The graft material with atelocollagen seemed to improve the new bone formation; however, other studies are needed to compare regenerated tissue properties over the time.
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CASE REPORTS Top

Utilization of concentrated growth factor as a sole sinus augmentation material p. 95
Kayvon Javi, Gregori M Kurtzman, Mariam Nadi, Hossein Javi
DOI:10.4103/GFSC.GFSC_12_18  
Posterior maxillary tooth loss frequently coincides with loss of available bone volume for implant placement due to both atrophy of the residual crestal bone and enlargement of the maxillary sinus. The longer the teeth have been missing, the greater the loss of osseous structure that may house implants. This necessitates augmentation of the maxillary sinus to provide adequate bone to place implants. Maxillary sinus augmentation with various bone graft material have become routine treatment over the past 38 years. Various materials have been utilized including allografts, xenografts and synthetics with varying levels of success as measured by the amount of graft maturation and its density to support implants following healing. As the use of autogenous blood products has increased in dental surgery for both soft and hard tissue applications, those materials have expanded into use when augmenting the sinus. As blood biology has grown in use with regard to grafting using the patients own blood to supply growth factors and other patient derived products, grafting has improved the clinical results we are able to achieve. These blood derived products have been mixed with packed osseous graft materials to help improve the quality and quantity of the resulting graft following healing. The case presented in this article demonstrates graft maturation as evidenced by density can be achieved using CGF alone with no added osseous graft materials. The benefit of this approach is no issues with the potential of a patient reaction to the packaged osseous graft material that are typically used and cost of treatment is reduced as packaged products are not utilized in the sinus augmentation procedure.
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Tomographic and clinical findings, pre-, trans-, and post-operative, of osseodensification in immediate loading p. 101
Rafael Coutinho Mello Machado, Cristiane Santos da Gama, Sandro Henrique Batista, Denise Rizzo, Helder Valiense, Ruda F Moreira
DOI:10.4103/GFSC.GFSC_22_18  
The advance of surgical techniques and modifications with respect to the surface and macrogeometry of dental implants, such as immediate and early loading, can help reduce the time of rehabilitation for the patient when excellent primary stability is the primary prerequisite. Starting from this principle, studies using a novel technique to replace bone-subtractive drilling have been developed to optimize the implant site. This new technique, called osseodensification, was developed by Dr. Salah Huwais and patented in 2012. The name of the procedure suggests the induction of a compression wave at the tip of specially designed drills at the point of contact. This case report suggests that the clinical and radiographic results obtained could support the hypothesis that a true gain in primary stability as well as a compaction grafting can be achieved by the use of this technique.
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